As the century draws to an end, a mysterious killing force suddenly plagues Metropolis. Unaware of who or what is on the rampage, Superman and Lois Lane launch an investigation that uncovers an amazing revelation: the destructive entity unleashed on the city is the son of Lex Luthor's ex-wife, the enigmatic Contessa. Now, to stem the tide of a bloody massacre, Superman must deduce the secret of Contessa's shadowy origin and apparent immortality in order to take down her deranged and super-powered offspring.
