The Quacks of Quedlinburg: The Herb Witches expands the town of Quedlinburg with four new sets of items:
- The Witches - new characters with special abilities that players may use once per game
- Locoweed - a new ingredient whose value is determined by its ability rather than being fixed
- New ingredient books for each existing ingredient type, increasing variety even further
- Player components in black color - increasing the number of players to 5