In Video Game High School, players take on the role of students from an alternative school where their classwork is all about preparing for careers as professional video gamers. Each student has unique player powers that they will use to their advantage as they select from a limited allotment of actions to train their gaming skills, take on challengers, and set high scores in various video games. The goal of the game is to climb the player ranks and become the top ranked gamer at VGHS.